Antigen presentation and adaptive immune responses in skin

For the induction of adequate cutaneous immune responses, the antigen presentation and recognition that occur in both the skin and skin-draining lymph nodes are essential. In each process of cutaneous immune responses, several distinct subsets of immune cells, including dendritic cells and T cells,...

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Bibliographic Details
Published in:International immunology 2019-07, Vol.31 (7), p.423-429
Main Authors: Honda, Tetsuya, Egawa, Gyohei, Kabashima, Kenji
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Animals
Antigen Presentation - immunology
Humans
Skin - immunology
Skin - pathology
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Summary:For the induction of adequate cutaneous immune responses, the antigen presentation and recognition that occur in both the skin and skin-draining lymph nodes are essential. In each process of cutaneous immune responses, several distinct subsets of immune cells, including dendritic cells and T cells, are involved, and they elicit their respective functions in a harmonious manner. For example, in the elicitation phase of cutaneous acquired immunity, immune cells form a specific lymphoid structure named inducible skin-associated lymphoid tissue (iSALT) to facilitate efficient antigen presentation in situ. In this short review, we will overview the mechanisms of how antigens are presented and how cutaneous adaptive immune responses are conducted in the skin, especially focusing on contact hypersensitivity, a prototypic adaptive immune response in the skin.
ISSN:1460-2377
1460-2377
DOI:10.1093/intimm/dxz005