Fingerprinting of traditionally produced red wines using liquid chromatography combined with drift tube ion mobility-mass spectrometry

The characterization of wine via MS-based metabolic fingerprinting techniques remains a challenging undertaking due to the large number of phenolic compounds that cannot be confidently annotated and identified within analytical workflows. The combination of high performance liquid chromatography wit...

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Bibliographic Details
Published in:Analytica chimica acta 2019-04, Vol.1052, p.179-189
Main Authors: Causon, Tim J., Ivanova-Petropulos, Violeta, Petrusheva, Dragana, Bogeva, Elena, Hann, Stephan
Format: Article
Language:English
Subjects:
CCS
Chromatography
Chromatography, Liquid - methods
Drift
Drift tubes
Fingerprinting
High performance liquid chromatography
HPLC
Ion Mobility Spectrometry - methods
Ion mobility-mass spectrometry
Ionic mobility
Ionization
Ions
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolomics
Mobility
Phenolic compounds
Phenols
Quality Control
Retention
Retention time
Scientific imaging
Spectroscopy
Wine
Wine - analysis
Wines
Workflow
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Summary:The characterization of wine via MS-based metabolic fingerprinting techniques remains a challenging undertaking due to the large number of phenolic compounds that cannot be confidently annotated and identified within analytical workflows. The combination of high performance liquid chromatography with low-field drift tube ion mobility time-of-flight mass spectrometry (HPLC × IMS-TOFMS) offers potential for the confident characterization and fingerprinting of wine using a metabolomics-type workflow. In particular, the use of collision cross section values from low-field drift tube IMS using nitrogen as drift gas (DTCCSN2) in addition to retention time and a high resolution mass spectrum for putative compounds allows rugged statistical assessment and identity confirmation using CCS libraries (
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2018.11.040