Serial Optical Coherence Tomography at Baseline, 7 Days, and 1, 3, 6 and 12 Months After Bioresorbable Scaffold Implantation in a Growing Porcine Model

• Published in: Circulation Journal 2019/02/25, Vol.83(3), pp.556-566
• Main Authors: Asano, Taku, Hytönen, Jarkko, Chichareon, Ply, Taavitsainen, Jouni, Kogame, Norihiro, Katagiri, Yuki, Miyazaki, Yosuke, Takahashi, Kuniaki, Modolo, Rodrigo, Komiyama, Hidenori, Tenekecioglu, Erhan, Sotomi, Yohei, Wykrzykowska, Joanna J., Piek, Jan J., Martin, John, Baumbach, Andreas, Mathur, Anthony, Onuma, Yoshinobu, Ylä-Herttuala, Seppo, Serruys, Patrick W.
• Format: Article
• Language: English
• Subjects: Absorbable Implants - standards; Animals; Coronary Angiography - methods; Coronary artery disease; Coronary Vessels - diagnostic imaging; Coronary Vessels - growth & development; Coronary Vessels - surgery; Models, Animal; Pediatrics; Percutaneous coronary intervention; Prosthesis Design - standards; Stent; Stents - standards; Swine; Time Factors; Tomography, Optical Coherence - methods
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-18-0855

Background: Little is known about serial changes in lumen and device dimensions after bioresorbable scaffold implantation in a growing animal model. Methods and Results: ABSORB (n=14) or bare metal stents (ICROS amg [Abbott Vascular, Santa Clara, CA, USA], Winsen-Luhe, Germany; n=15) were implanted in the coronary arteries of domestic swine (a hybrid of Finnish-Norwegian Landrace swine) weighing 30–35 kg. Angiography and optical coherence tomography (OCT) were performed immediately after implantation and repeated at 7 days, 1, 3, 6 and 12 months after the index procedure. One month after implantation, mean lumen area decreased relative to baseline in both groups (relative area change from baseline, −41.4±15.6% for ABSORB vs. −20.9±18.6% for ICROS) while mean device area decreased only in the ABSORB group (relative area change: −11.1±9.4% vs. +0.14±7.95%, respectively). At 12 months, mean lumen area increased relative to baseline in both groups (relative area change from baseline, +55.6±22.4% vs. +32.3±83.6%, respectively) in accordance with the swine growth weighing up to 260–300 kg. Mean device area in the ICROS group remained stable whereas that in the ABSORB group began to increase between 3 and 6 months along with the vessel growth (relative area change: +107.8±25.7% vs. +0.14±7.95%). Conclusions: In the growing porcine model, ABSORB was associated with greater extent of recoil 1 month after implantation compared with ICROS but demonstrated substantial adaptability to vessel growth in late phase.