Autologous cancer cell-derived extracellular vesicles as drug-delivery systems: a systematic review of preclinical and clinical findings and translational implications

Extracellular vesicles (EVs) are nanoscale natural membrane vesicles released by cells and are involved in intercellular communication. A number of studies have used autologous cancer cell-derived EVs (ACCD-EVs) as nanocarriers for delivery of therapeutics as they may be more efficiently uptaken by...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-02, Vol.14 (4), p.493-509
Main Authors: Li, Yong-Jiang, Wu, Jun-Yong, Hu, Xiong-Bin, Wang, Jie-Min, Xiang, Da-Xiong
Format: Article
Language:English
Subjects:
biodistribution
cancer
Cancer therapies
Cell growth
Clinical trials
drug delivery
Drug delivery systems
Drug resistance
exosome
Extracellular vesicles
Metastasis
MicroRNAs
microvesicles
nanomedicine
Nanoparticles
purification
Search strategies
Studies
Systematic review
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Summary:Extracellular vesicles (EVs) are nanoscale natural membrane vesicles released by cells and are involved in intercellular communication. A number of studies have used autologous cancer cell-derived EVs (ACCD-EVs) as nanocarriers for delivery of therapeutics as they may be more efficiently uptaken by the cancer cells themselves. However, they also have been suggested to promote proliferation, survival and metastasis of cancers. Here, we evaluated the targeting efficacy, therapeutic outcome and safety of ACCD-EVs. Overall, superior targeting efficacy and enhanced anticancer efficacy of ACCD-EV-mediated delivery of therapeutics are evidenced. But existing data are insufficient to allow any conclusion about the safety of therapeutic-loaded EVs. A more profound elucidation of the specificity, efficacy and safety will contribute to future translational research of ACCD-EVs.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2018-0286