Obesity is associated with altered gene expression in human tastebuds

Background The role of taste perception in the development and persistence of obesity is currently unclear due to conflicting results from psychophysical and other studies. No study to date has assessed whether there is an underlying fundamental difference in the physiology of taste tissue between l...

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Bibliographic Details
Published in:International Journal of Obesity 2019-07, Vol.43 (7), p.1475-1484
Main Authors: Archer, Nicholas, Shaw, Jan, Cochet-Broch, Maeva, Bunch, Rowan, Poelman, Astrid, Barendse, William, Duesing, Konsta
Format: Article
Language:English
Subjects:
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Adolescent
Adult
Analysis
Body Mass Index
Development and progression
Epidemiology
Female
Gene expression
Genes
Genetic aspects
Health aspects
Health Promotion and Disease Prevention
Hedgehog protein
Humans
Immune response
Immune system
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Obesity
Obesity - genetics
Obesity - metabolism
Papillae
Phospholipase
Phospholipase C
Psychophysics
Public Health
Ribonucleic acid
RNA
Sensory perception
Signal transduction
Synaptic transmission
Taste
Taste - genetics
Taste buds
Taste Perception
Tongue - chemistry
Transcriptome - genetics
Young Adult
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Summary:Background The role of taste perception in the development and persistence of obesity is currently unclear due to conflicting results from psychophysical and other studies. No study to date has assessed whether there is an underlying fundamental difference in the physiology of taste tissue between lean and obese individuals. Method/subjects We analysed the transcriptomic profile (RNA-seq) of human fungiform taste papillae biopsied from lean ( n  = 23) and obese ( n  = 13) Caucasian females (age range 18–55) to identify differences in gene expression. Results Obesity status was the major contributor to variance in global gene expression between individuals. A total of 62 genes had significantly different gene expression levels between lean and obese ( P  
ISSN:0307-0565
1476-5497
DOI:10.1038/s41366-018-0303-y