Squamous cell carcinoma of the bladder: poor response to neoadjuvant chemotherapy

Background Squamous cell carcinoma (SCC) of the bladder is a rare, aggressive malignancy. Unlike urothelial cell carcinoma, SCC is resistant to chemotherapy and guidelines recommend radical cystectomy (RC) without neoadjuvant chemotherapy (NAC). We aimed to evaluate the current management and surviv...

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Bibliographic Details
Published in:International journal of clinical oncology 2019-06, Vol.24 (6), p.706-711
Main Authors: Dotson, Aaron, May, Allison, Davaro, Facundo, Raza, Syed Johar, Siddiqui, Sameer, Hamilton, Zachary
Format: Article
Language:English
Subjects:
Bladder
Bladder cancer
Cancer Research
Chemotherapy
Invasiveness
Malignancy
Medicine
Medicine & Public Health
Mortality
Oncology
Original Article
Patients
Squamous cell carcinoma
Surgical Oncology
Survival analysis
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Summary:Background Squamous cell carcinoma (SCC) of the bladder is a rare, aggressive malignancy. Unlike urothelial cell carcinoma, SCC is resistant to chemotherapy and guidelines recommend radical cystectomy (RC) without neoadjuvant chemotherapy (NAC). We aimed to evaluate the current management and survival of patients with invasive SCC treated with or without NAC. Methods 671 patients with invasive SCC bladder cancer from 2004 to 2015 in the National Cancer Data Base were identified. Patients were stratified by treatment with RC alone or NAC prior to RC (NAC + RC). Survival analysis was performed with Kaplan–Meier and Cox regression. Secondary outcomes included length of stay and readmission. Results Of 671 patients, 92.8% were treated with RC alone and 7.2% with NAC + RC. Cox regression for mortality was performed including age, Charlson score, clinical stage, and NAC. Increased risk of mortality was noted with increasing age (OR 1.01, p  = 0.023) and Charlson score of 1–3 (HR 1.58–1.68, p  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-019-01409-x