Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: The zebrafish model

[Display omitted] The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic determinants and can be modulated pharmacologically in humans and animal model species. Mounting...

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Bibliographic Details
Published in:Pharmacological research 2019-03, Vol.141, p.602-608
Main Authors: de Abreu, Murilo S., Giacomini, Ana C.V.V., Genario, Rafael, dos Santos, Bruna E., da Rosa, Larissa G., Demin, Konstantin A., Wappler-Guzzetta, Edina A., Kalueff, Allan V.
Format: Article
Language:English
Subjects:
Aggression
Aggression - drug effects
Animal models
Animals
Central Nervous System Agents - pharmacology
Central Nervous System Diseases - drug therapy
Central Nervous System Diseases - genetics
Central Nervous System Diseases - pathology
CNS
Disease Models, Animal
Epigenetics
Neuropharmacology
Pharmacogenetics
Pharmacological modulation
Translational Medical Research
Zebrafish - genetics
Zebrafish - physiology
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Summary:[Display omitted] The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic determinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Here, we discuss mechanisms of zebrafish aggression and their pharmacological, pharmacogenetic and pharmacogenomic models, as well as recent developments and existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of aggression, fostering future discoveries of potential therapeutic agents for aggressive behavior.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2019.01.044