Fixed Dose Combination Formulations: Multilayered Platforms Designed for the Management of Cardiovascular Disease

• Published in: Molecular pharmaceutics 2019-05, Vol.16 (5), p.1827-1838
• Main Authors: Andrews, G. P, Li, S, Almajaan, A, Yu, T, Martini, L, Healy, A, Jones, D. S
• Format: Article
• Language: English
• Subjects: Aspirin - administration & dosage; Aspirin - chemistry; Cardiovascular Diseases - complications; Cardiovascular Diseases - drug therapy; Dosage Forms; Drug Combinations; Drug Compounding - methods; Drug Delivery Systems - methods; Drug Design; Drug Liberation; Hot Melt Extrusion Technology - methods; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry; Hyperlipidemias - complications; Hyperlipidemias - drug therapy; Polyethylene Glycols - chemistry; Polyvinyls - chemistry; Pyrrolidines - chemistry; Simvastatin - administration & dosage; Simvastatin - chemistry; Solubility; Vinyl Compounds - chemistry
• ISSN: 1543-8384; 1543-8392
• DOI: 10.1021/acs.molpharmaceut.8b01068

Hyperlipidaemia is considered as one of the main risk factors associated with cardiovascular diseases (CVDs). Among different lipid-lowering agents used to manage hyperlipidaemia, statins are highly prescribed for management of hyperlipidaemia with simvastatin being one of the most common. Simvastatin is susceptible to extensive metabolism by CYP450 3A4 and 3A5, which are expressed both in the liver and the gastrointestinal tract. Nevertheless, the localization of these enzymes is site-dependent with lower concentration at the distal/proximal regions of the small intestine/colon. In addition to statins, medications such as antihypertensive agents and anticoagulants are introduced as adjuvants, for the treatment of cardiovascular disease. The aim of this study was to design a bilayer delivery system capable of delivering biphasic release of simvastatin and aspirin, within a fixed dose combination. A delayed release platform based on a combination of anionic polymers prepared using hot-melt extrusion was developed to delay the release of simvastatin. An optimized formulation tested for dissolution performance clearly demonstrated an ability to delay the release of simvastatin. In addition, an immediate release layer based on Kollidon VA64 was successfully developed to deliver aspirin. Both formulations were then manufactured as a bilayer drug delivery system (tablets and coextrudates), and the release performance was examined. On the basis of the obtained results, these formulations may be used as a platform for delivering a wide range of medications in a biphasic manner.