The Potential Role of Dysregulated miRNAs in Alzheimer’s Disease Pathogenesis and Progression

Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that affects the cognitive faculties of millions of people worldwide. There is still no known cure for AD, nor a clear understanding of AD etiology. Nevertheless, researchers have made significant strides in understanding various k...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2019-01, Vol.67 (4), p.1123-1145
Main Authors: Patel, Ankur A., Ganepola, Ganepola A.P., Rutledge, John R., Chang, David H.
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - psychology
Alzheimer Disease - therapy
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Circulating MicroRNA - analysis
Cognitive ability
Drug Discovery
Etiology
Global health
Health risks
Humans
Memory, Long-Term - physiology
miRNA
Neurodegenerative diseases
Neurofibrillary Tangles - metabolism
Neurological diseases
Pathogenesis
Ribonucleic acid
RNA
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Summary:Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that affects the cognitive faculties of millions of people worldwide. There is still no known cure for AD, nor a clear understanding of AD etiology. Nevertheless, researchers have made significant strides in understanding various key aspects of AD neuropathology at the cellular and molecular levels. This review is intended to provide a general survey of what is known and unknown, based on the three hallmarks of AD, combined with our knowledge from microRNA research. Our goal is to reevaluate and reassess the current direction of AD research and therapeutic insights, charting a new course and comprehensive plan to combat this imminent global health threat.
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-181078