Loading…
Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis
Background The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS. Methods A comprehensive literature search was performed in Pubm...
Saved in:
| Published in: | European journal of clinical investigation 2019-04, Vol.49 (4), p.e13074-n/a |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403 |
| container_end_page | n/a |
| container_issue | 4 |
| container_start_page | e13074 |
| container_title | European journal of clinical investigation |
| container_volume | 49 |
| creator | He, Cuifang Lin, Peihuan Liu, Wenbing Fang, Kuaifa |
| description | Background
The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS.
Methods
A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all‐cause mortality or cardiovascular mortality.
Results
A total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47‐2.35), all‐cause mortality (RR 1.86; 95% CI: 1.49‐2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36‐2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups.
Conclusions
This meta‐analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients. |
| doi_str_mv | 10.1111/eci.13074 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179529741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179529741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403</originalsourceid><addsrcrecordid>eNp10M1KxDAQB_Agiq4fB19AAl70UM00bdN4Wxa_YEEPepSSprOapW3WpHXpzUfwGX0So6seBOcylx9_Zv6E7AM7gTCnqM0JcCaSNTICnqVRzLN4nYwYgySKpYi3yLb3c8ZYDjzeJFvBMkhjOSIPt84-ttZ3RtMXVfdI7Yw-DQt0vTMaG6OoaelCdQbbztOl6Z6o0n2HVFtnW-UG6oe2crbBMzqmDXbq_fVNtaoevPG7ZGOmao9733uH3F-c302uounN5fVkPI00T3kSiYSLTCqosGIgZIxlBgmrZlnKMauUKBnnZQ6ZzGWVp0omAkCkrCwZSl0mjO-Qo1XuwtnnHn1XNMZrrGvVou19EYfU8K5IINDDP3Ruexfu_VRS5BI4iKCOV0o7673DWbFwpgnfFsCKz86L0Hnx1XmwB9-Jfdlg9St_Sg7gdAWWpsbh_6TifHK9ivwAybyK3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2197891317</pqid></control><display><type>article</type><title>Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>He, Cuifang ; Lin, Peihuan ; Liu, Wenbing ; Fang, Kuaifa</creator><creatorcontrib>He, Cuifang ; Lin, Peihuan ; Liu, Wenbing ; Fang, Kuaifa</creatorcontrib><description>Background
The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS.
Methods
A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all‐cause mortality or cardiovascular mortality.
Results
A total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47‐2.35), all‐cause mortality (RR 1.86; 95% CI: 1.49‐2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36‐2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups.
Conclusions
This meta‐analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.13074</identifier><identifier>PMID: 30701529</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>acute coronary syndrome ; Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - mortality ; Acute Coronary Syndrome - urine ; Acute coronary syndromes ; Biomarkers - metabolism ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - urine ; Cause of Death ; Confidence intervals ; Female ; Health risk assessment ; Humans ; Hyperuricemia ; Hyperuricemia - complications ; Hyperuricemia - mortality ; major adverse cardiac events ; Male ; Meta-analysis ; Middle Aged ; Mortality ; Patients ; Prognosis ; Risk analysis ; Risk Factors ; Subgroups ; Uric acid</subject><ispartof>European journal of clinical investigation, 2019-04, Vol.49 (4), p.e13074-n/a</ispartof><rights>2019 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>2019 Stichting European Society for Clinical Investigation Journal Foundation.</rights><rights>Copyright © 2019 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403</citedby><cites>FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403</cites><orcidid>0000-0002-9774-9426</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30701529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Cuifang</creatorcontrib><creatorcontrib>Lin, Peihuan</creatorcontrib><creatorcontrib>Liu, Wenbing</creatorcontrib><creatorcontrib>Fang, Kuaifa</creatorcontrib><title>Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background
The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS.
Methods
A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all‐cause mortality or cardiovascular mortality.
Results
A total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47‐2.35), all‐cause mortality (RR 1.86; 95% CI: 1.49‐2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36‐2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups.
Conclusions
This meta‐analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.</description><subject>acute coronary syndrome</subject><subject>Acute Coronary Syndrome - complications</subject><subject>Acute Coronary Syndrome - mortality</subject><subject>Acute Coronary Syndrome - urine</subject><subject>Acute coronary syndromes</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cardiovascular Diseases - urine</subject><subject>Cause of Death</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hyperuricemia</subject><subject>Hyperuricemia - complications</subject><subject>Hyperuricemia - mortality</subject><subject>major adverse cardiac events</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Subgroups</subject><subject>Uric acid</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10M1KxDAQB_Agiq4fB19AAl70UM00bdN4Wxa_YEEPepSSprOapW3WpHXpzUfwGX0So6seBOcylx9_Zv6E7AM7gTCnqM0JcCaSNTICnqVRzLN4nYwYgySKpYi3yLb3c8ZYDjzeJFvBMkhjOSIPt84-ttZ3RtMXVfdI7Yw-DQt0vTMaG6OoaelCdQbbztOl6Z6o0n2HVFtnW-UG6oe2crbBMzqmDXbq_fVNtaoevPG7ZGOmao9733uH3F-c302uounN5fVkPI00T3kSiYSLTCqosGIgZIxlBgmrZlnKMauUKBnnZQ6ZzGWVp0omAkCkrCwZSl0mjO-Qo1XuwtnnHn1XNMZrrGvVou19EYfU8K5IINDDP3Ruexfu_VRS5BI4iKCOV0o7673DWbFwpgnfFsCKz86L0Hnx1XmwB9-Jfdlg9St_Sg7gdAWWpsbh_6TifHK9ivwAybyK3w</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>He, Cuifang</creator><creator>Lin, Peihuan</creator><creator>Liu, Wenbing</creator><creator>Fang, Kuaifa</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9774-9426</orcidid></search><sort><creationdate>201904</creationdate><title>Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis</title><author>He, Cuifang ; Lin, Peihuan ; Liu, Wenbing ; Fang, Kuaifa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>acute coronary syndrome</topic><topic>Acute Coronary Syndrome - complications</topic><topic>Acute Coronary Syndrome - mortality</topic><topic>Acute Coronary Syndrome - urine</topic><topic>Acute coronary syndromes</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Cardiovascular Diseases - urine</topic><topic>Cause of Death</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hyperuricemia</topic><topic>Hyperuricemia - complications</topic><topic>Hyperuricemia - mortality</topic><topic>major adverse cardiac events</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Subgroups</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Cuifang</creatorcontrib><creatorcontrib>Lin, Peihuan</creatorcontrib><creatorcontrib>Liu, Wenbing</creatorcontrib><creatorcontrib>Fang, Kuaifa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Cuifang</au><au>Lin, Peihuan</au><au>Liu, Wenbing</au><au>Fang, Kuaifa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2019-04</date><risdate>2019</risdate><volume>49</volume><issue>4</issue><spage>e13074</spage><epage>n/a</epage><pages>e13074-n/a</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS.
Methods
A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all‐cause mortality or cardiovascular mortality.
Results
A total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47‐2.35), all‐cause mortality (RR 1.86; 95% CI: 1.49‐2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36‐2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups.
Conclusions
This meta‐analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30701529</pmid><doi>10.1111/eci.13074</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9774-9426</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2972 |
| ispartof | European journal of clinical investigation, 2019-04, Vol.49 (4), p.e13074-n/a |
| issn | 0014-2972 1365-2362 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179529741 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | acute coronary syndrome Acute Coronary Syndrome - complications Acute Coronary Syndrome - mortality Acute Coronary Syndrome - urine Acute coronary syndromes Biomarkers - metabolism Cardiovascular diseases Cardiovascular Diseases - mortality Cardiovascular Diseases - urine Cause of Death Confidence intervals Female Health risk assessment Humans Hyperuricemia Hyperuricemia - complications Hyperuricemia - mortality major adverse cardiac events Male Meta-analysis Middle Aged Mortality Patients Prognosis Risk analysis Risk Factors Subgroups Uric acid |
| title | Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T13%3A57%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20of%20hyperuricemia%20in%20patients%20with%20acute%20coronary%20syndrome:%20A%20meta%E2%80%90analysis&rft.jtitle=European%20journal%20of%20clinical%20investigation&rft.au=He,%20Cuifang&rft.date=2019-04&rft.volume=49&rft.issue=4&rft.spage=e13074&rft.epage=n/a&rft.pages=e13074-n/a&rft.issn=0014-2972&rft.eissn=1365-2362&rft_id=info:doi/10.1111/eci.13074&rft_dat=%3Cproquest_cross%3E2179529741%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3534-743769a1ded01792eb6140df653e6da7b033b816989d85a94711750bb0e9cb403%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2197891317&rft_id=info:pmid/30701529&rfr_iscdi=true |