Early post‐operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus

We aimed to compare the early results of i.v. with p.o. TAC as a primary immunosuppressant in pediatric patients undergoing LT. This retrospective study enrolled 75 children who underwent LT and received TAC‐steroid regimens as a primary immunosuppressant between September 2011 and October 2015 at o...

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Bibliographic Details
Published in:Pediatric transplantation 2019-05, Vol.23 (3), p.e13368-n/a
Main Authors: Sabra, Tarek Abdelazeem, Okajima, Hideaki, Yoshizawa, Atsushi, Ogawa, Eri, Okamoto, Shinya, Osman, Mohamed Abdelkader, Saad‐Eldin, Yasser, Uemoto, Shinji
Format: Article
Language:English
Subjects:
ACR
Administration, Oral
Biopsy
Child
Child, Preschool
Creatinine
Cytomegalovirus Infections - etiology
Female
Graft Rejection
Graft Survival
Humans
Immunosuppressive Agents - administration & dosage
Intravenous administration
Length of Stay
Liver - pathology
Liver Failure - surgery
Liver Transplantation
Liver transplants
Male
Patients
pediatric liver transplantation
Pediatrics
Postoperative Period
Renal function
Retrospective Studies
Side effects
Steroids
TAC
Tacrolimus
Tacrolimus - administration & dosage
Treatment Outcome
viral infection
Viral infections
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Summary:We aimed to compare the early results of i.v. with p.o. TAC as a primary immunosuppressant in pediatric patients undergoing LT. This retrospective study enrolled 75 children who underwent LT and received TAC‐steroid regimens as a primary immunosuppressant between September 2011 and October 2015 at our institution. Thirty‐five recipients received TAC i.v. and 40 received TAC p.o. Early results were evaluated and compared, including ACR, EBV, or CMV infection; renal adverse effects; and hospital stay. Comparisons of 90‐day post‐transplant results showed that the rates of overall viral (74% vs 40% P 
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13368