Pharmacokinetics of cefquinome after single and repeated subcutaneous administrations in sheep

• Published in: Journal of veterinary pharmacology and therapeutics 2019-11, Vol.42 (6), p.647-653
• Main Authors: Corum, Orhan, Corum, Duygu Durna, Er, Ayse, Uney, Kamil
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; Bacteria - drug effects; bioavailability; cefquinome; Cephalosporins - administration & dosage; Cephalosporins - blood; Cephalosporins - pharmacokinetics; Drug Administration Schedule; Half-Life; Injections, Subcutaneous; Microbial Sensitivity Tests; pharmacokinetics; sheep; Sheep - blood; Sheep - metabolism; subcutaneous
• ISSN: 0140-7783; 1365-2885
• DOI: 10.1111/jvp.12750

The purpose of this study was to determine the pharmacokinetics of cefquinome (CFQ) following single and repeated subcutaneous (SC) administrations in sheep. Six clinically healthy, 1.5 ± 0.2 years sheep were used for the study. In pharmacokinetic study, the crossover design in three periods was performed. The withdrawal interval between the study periods was 15 days. In first period, CFQ (Cobactan, 2.5%) was administered by an intravenous (IV) bolus (3 sheep) and SC (3 sheep) injections at 2.5 mg/kg dose. In second period, the treatment administration was repeated via the opposite administration route. In third period, CFQ was administrated subcutaneously to each sheep (n = 6) at a dose of 2.5 mg/kg q. 24 hr for 5 days. Plasma concentrations of CFQ were measured using the HPLC‐UV method. Pharmacokinetic parameters were calculated using non‐compartmental methods. The elimination half‐life and mean residence time of CFQ after the single SC administration were longer than IV administration (p