Reduced axial diffusivity and increased mode and T2 signals in cerebral white matter of chronic obstructive pulmonary disease using tract-based spatial statistics

Purpose Chronic obstructive pulmonary disease (COPD) is considered to be a multi-systemic disease involving pathological changes in the brain. This study investigated how diffusion tensor imaging (DTI) parameters in patients with non-hypoxemic COPD differ from those in controls. Moreover, we tried t...

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Bibliographic Details
Published in:Neuroradiology 2019-07, Vol.61 (7), p.795-801
Main Authors: Lee, Sekwang, Pyun, Sung-Bom, Tae, Woo-Suk
Format: Article
Language:English
Subjects:
Aged
Anisotropy
Automatic control
Brain
Cerebellum
Chronic obstructive pulmonary disease
Corpus callosum
Diagnostic Neuroradiology
Diffusion Tensor Imaging - methods
Hippocampus
Humans
Imaging
Integrity
Lemniscus (medial)
Lung diseases
Magnetic resonance imaging
Male
Medical imaging
Medicine
Medicine & Public Health
Mesencephalon
Neuroimaging
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Obstructive lung disease
Patients
Pons
Pulmonary Disease, Chronic Obstructive
Pyramidal tracts
Radiology
Scalars
Statistical analysis
Subiculum
Substantia alba
Tensors
Thalamus
Tonsil
White Matter - pathology
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Summary:Purpose Chronic obstructive pulmonary disease (COPD) is considered to be a multi-systemic disease involving pathological changes in the brain. This study investigated how diffusion tensor imaging (DTI) parameters in patients with non-hypoxemic COPD differ from those in controls. Moreover, we tried to examine whether the mode of anisotropy (MO) reflects early changes in white matter (WM) integrity in COPD. Methods DT images were obtained from 13 male COPD patients and 13 age- and sex-matched healthy controls. Raw DT images were processed using an automated tract-based spatial statistics (TBSS) pipeline. DTI scalars of fractional anisotropy (FA); axial, radial, and mean diffusivities (AD, RD, and MD, respectively); MO; and raw T2 signal (S0) were statistically compared between COPD patients and controls. TBSS methods were used for analysis. Results In patients with COPD, decreased AD was observed in the temporal stem (TS), corticospinal tract (CST), thalamus, subiculum, crus cerebri, and midbrain. Increased MO values were found in the corpus callosum, CST, internal capsule, cerebellar peduncle (CP), and medial lemniscus (ML). Additionally, increased S0 was found in the TS, CP, pons, and cerebellar tonsil (threshold-free cluster enhancement to a family-wise error rate of p  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-019-02178-0