A hybrid small‐diameter tube fabricated from decellularized aortic intima‐media and electrospun fiber for artificial small‐diameter blood vessel

Hybrid small‐diameter tubes were fabricated by wrapping decellularized aortic intima‐media sheets around a tubular stainless steel mandrel with diameter 4 mm, and then by coating with electrospun segmented polyurethane. The synthetic coat was deposited uniformly to a thickness of about 0.5–3.5 μm de...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2019-05, Vol.107 (5), p.1064-1070
Main Authors: Wu, Pingli, Nakamura, Naoko, Morita, Hiroko, Nam, Kwangwoo, Fujisato, Toshiya, Kimura, Tsuyoshi, Kishida, Akio
Format: Article
Language:English
Subjects:
Aorta
Biocompatibility
Blood vessels
Bursting strength
decellularized aortic intima‐media
Electrospinning
Endothelial cells
Fibers
Fibroblasts
mechanical compliance
Mechanical properties
Morphology
Polyurethane
Polyurethane resins
Skin
small‐diameter blood vessel
Stainless steel
Stainless steels
Stiffness
Thickness
Tubes
Umbilical vein
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Summary:Hybrid small‐diameter tubes were fabricated by wrapping decellularized aortic intima‐media sheets around a tubular stainless steel mandrel with diameter 4 mm, and then by coating with electrospun segmented polyurethane. The synthetic coat was deposited uniformly to a thickness of about 0.5–3.5 μm depending on the duration of electrospinning. Resistance to luminal pressure, burst strength, and stiffness increased with the thickness of the electrospun coat, suggesting that the synthetic fabric reinforces the reconstructed acellular aortic intima‐media. Human umbilical vein endothelial cells seeded on the inner surface acquired flagstone morphology, while normal human dermal fibroblasts seeded on the outer surface proliferated well and partly migrated into deeper layers. Collectively, the data suggest that reinforcing decellularized aortic intima‐media with electrospun fibers generates a small‐diameter hybrid blood vessel with good biocompatibility and suitable mechanical properties. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1064–1070, 2019.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36631