Chitosan‐based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects

Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that ha...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-08, Vol.234 (8), p.12325-12340
Main Authors: Saheb, Mahsa, Fereydouni, Narges, Nemati, Saeideh, Barreto, George E., Johnston, Thomas P., Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Animals
Bioavailability
Biocompatibility
Biodegradability
Biodegradation
Biological Availability
Chemical compounds
Chitosan
Chitosan - chemistry
Curcumin
Curcumin - chemistry
Curcumin - pharmacokinetics
Curcumin - pharmacology
Drug Carriers - chemistry
Drug delivery
Drug delivery systems
Humans
Hydrophobicity
Nanoparticles - chemistry
Neoplasms - drug therapy
Pharmacodynamics
Pharmacokinetics
Pharmacology
Polymers
Solubility
System effectiveness
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Summary:Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water‐soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan‐based delivery of curcumin. Curcumin has potent analgesic and anti‐inflammatory properties. The aqueous solubility and oral bioavailability of curcumin can be enhanced to improve its effects. Chitosan‐based delivery of curcumin can be used as a novel therapeutic strategy to improve its efficacy.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28024