NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans

•Natural solvents showed outstanding performance as plant biocompounds vehicle.•Antifungal activity of Larrea extracts were higher than their individual compounds.•Topical formulations prepared with Larrea extracts showed satisfactory performance. Candida albicans is an opportunistic pathogenic yeas...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2019-04, Vol.167, p.15-20
Main Authors: Espino, Magdalena, Solari, Manuel, Fernández, María de los Ángeles, Boiteux, Joana, Gómez, María Roxana, Silva, María Fernanda
Format: Article
Language:English
Subjects:
Alkaloids
Candida albicans
Medicinal plants
NADES
Pharmaceutical formulations
Phenolic compounds
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Summary:•Natural solvents showed outstanding performance as plant biocompounds vehicle.•Antifungal activity of Larrea extracts were higher than their individual compounds.•Topical formulations prepared with Larrea extracts showed satisfactory performance. Candida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract and vagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern over the emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. In the present work, novel bioextracts from folk medicinal plants were directly used as active ingredient in a topical formulation for dermal candidiasis. With the aim to replace hazardous traditional reagents, a natural solvent composed by lactic acid: glucose: water (LGH) was used as vehicle for bioactive compound extraction. Furthermore, phenolic and alkaloid composition were determined by HPLC and their individual antifungal effect was evaluated. LGH extracts of Larrea spices demonstrate a significant antimicrobial activity against C. albicans being higher than their individual bioactive constituents. Notably, the mixture of Larrea cuneifolia and L divaricata extracts in topical formulations reveal a synergistic antifungal effect highlighting their potential for candidiasis treatment.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2019.01.026