Depth of anesthesia measured by bispectral index and postoperative mortality: A meta-analysis of observational studies

Whether anesthesia depth affects postoperative mortality remains uncertain. Several databases were systematically searched to identify all articles studying the relationship between depth of anesthesia and postoperative mortality. Post hoc subgroup analyses were conducted for follow-up period (30 da...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical anesthesia 2019-09, Vol.56, p.119-125
Main Authors: Liu, Yu-Hua, Qiu, Dong-Jie, Jia, Li, Tan, Jun-Tao, Kang, Jin-Meng, Xie, Tian, Xu, Hong-Meng
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia - adverse effects
Anesthesia - methods
Bispectral index
Cardiac Surgical Procedures - adverse effects
Confidence intervals
Consciousness Monitors
Depth of anesthesia
Hospital Mortality
Humans
Meta-analysis
Monitoring, Intraoperative - instrumentation
Monitoring, Intraoperative - methods
Mortality
Observational studies
Observational Studies as Topic
Patients
Postoperative Complications - etiology
Postoperative Complications - mortality
Postoperative mortality
Quality
Studies
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whether anesthesia depth affects postoperative mortality remains uncertain. Several databases were systematically searched to identify all articles studying the relationship between depth of anesthesia and postoperative mortality. Post hoc subgroup analyses were conducted for follow-up period (30 days vs. longer than 90 days) and type of surgery. The analysis included 38,722 patients from nine studies. We observed a significant relationship between low bispectral index (BIS) and mortality (pooled aHR, 1.22;95% CI, 1.08 to 1.38; P = 0.001; I2 = 85.4%). Post hoc subgroup analyses indicated low BIS to be linked with significantly elevated mortality risk in patients with ≥90 days follow-up (pooled adjusted hazard ratio [aHR], 1.09; 95% CI, 1.00–1.19; P = 0.01; I2 = 79.4%), but this association did not achieve significance in those with a 30 day follow-up duration (pooled aHR, 1.52; 95% CI, 0.97–2.38; P = 0.28; I2 = 79.0%). In addition, this link between postoperative mortality and low BIS was significant in those who had undergone cardiac surgery (pooled aHR, 1.30; 95% CI, 1.14 to 1.49; P 
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2019.01.046