The hemostasis system in children with hereditary spherocytosis

• Published in: Thrombosis research 2019-04, Vol.176, p.11-17
• Main Authors: Seregina, E.A., Poletaev, A.V., Bondar, E.V., Vuimo, T.A., Ataullakhanov, F.I., Smetanina, N.S.
• Format: Article
• Language: English
• Subjects: Adolescent; Blood coagulation; Child; Child, Preschool; Clotting times; Female; Fibrin Fibrinogen Degradation Products - analysis; Fibrinogen - analysis; Global hemostatic assays; Hemostasis; Hemostasis during hemolytic crisis in children; Hemostasis in hemolytic anemia; Hemostatic function; Humans; Hypercoagulability; Infant; Male; Spherocytosis, Hereditary - blood; Thrombelastography; Thrombodynamics; Thromboelastography; Thrombophilia - blood
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2019.02.004

Patients with hereditary spherocytosis (HS) are characterized by having an increased risk for thrombosis. An early manifestation of thrombotic complications can occur even in childhood, especially after surgery. Hypercoagulability can be associated with hemolytic crises. The aim of this study was to investigate the hemostatic state in children with HS using global hemostasis assays. The hemostatic status of 62 children (38 boys and 24 girls; age range: 0.5 to 17 years) with HS during and without hemolytic crisis was assessed using clotting times (APTT, TT, and PR), fibrinogen and D-dimer levels, and global hemostasis, thromboelastography (TEG) and thrombodynamics (TD) assays. One hundred and two healthy children undergoing annual medical examination were enrolled as a control group. TEG and TD parameters were increased in the children with HS compared to the control group (60 ± 5 mm vs. 53 ± 4 mm, p