Statin use among Veterans with dialysis‐dependent chronic kidney disease

• Published in: Hemodialysis international 2019-04, Vol.23 (2), p.206-213
• Main Authors: Markossian, Talar W., Kramer, Holly J., Burge, Nicholas J., Pacold, Ivan V., Leehey, David J., Huo, Zhiping, Schneider, Julia, Ling, Benjamin, Stroupe, Kevin T.
• Format: Article
• Language: English
• Subjects: Aged; cardiovascular disease; Chronic kidney disease; Cross-Sectional Studies; dialysis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; lipids; Male; Renal Dialysis - methods; Renal Insufficiency, Chronic - drug therapy; statins; United States; Veterans
• ISSN: 1492-7535; 1542-4758
• DOI: 10.1111/hdi.12730

Introduction: The benefits of statin medications in patients receiving maintenance dialysis remains controversial and clinical trials overall have shown no benefit. Potential side effects of statin medications include myalgias, myopathy, and memory loss and risk of side effects associated with statin medications increase with higher statin doses. We examined statin use and statin dose among Veterans with dialysis dependent CKD. Such information may help clinicians modulate medication use and reduce pill burden in appropriate patients. Methods: This cross‐sectional analysis ascertained medication utilization by linking records from the U.S. Department of Veteran's Affairs (VA) Managerial Cost Accounting Pharmacy National Data Extracts and Medicare Part D during calendar year 2013 for Veterans with dialysis‐dependent CKD enrolled in and/or using VA healthcare. The venue of dialysis and patient characteristics were ascertained by linking VA Medical SAS datasets, VA Fee Basis datasets (for non‐VA care paid for by VA), Medicare claims and the United States Renal Data Systems patient core files. Findings: We identified 18,494 Veterans with dialysis‐dependent CKD who were enrolled in and/or used VA healthcare, had no history of kidney transplantation, and were alive on January 1, 2014. More than half (58.1%) of Veterans with dialysis‐dependent CKD used statins and 35.7% of statin utilization was high dose. Statins were the third most commonly prescribed medication after beta blockers (64.8%) and phosphate binders (64.5%). Discussion: Statins are a commonly prescribed medication among Veterans receiving maintenance dialysis and approximately one‐third of statin utilization is high dose in this population. Future studies should examine patient preferences, comorbidities, and dialysis characteristics that impact the risks and benefits of statin use in order to identify those patients who will or will not benefit from continued statin use.