Association between PNPLA3rs738409 polymorphism decreased kidney function in postmenopausal type 2 diabetic women with or without non-alcoholic fatty liver disease

Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diab...

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Bibliographic Details
Published in:Diabetes & metabolism 2019-10, Vol.45 (5), p.480-487
Main Authors: Mantovani, A., Zusi, C., Sani, E., Colecchia, A., Lippi, G., Zaza, G.L., Valenti, L., Byrne, C.D., Maffeis, C., Bonora, E., Targher, G.
Format: Article
Language:English
Subjects:
Adiponutrin
Aged
Aged, 80 and over
Albuminuria - complications
Albuminuria - diagnosis
Albuminuria - physiopathology
Chronic kidney disease
CKD
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - physiopathology
Female
Genotype
Glomerular Filtration Rate - physiology
Humans
Kidney - physiopathology
Lipase - genetics
Membrane Proteins - genetics
Middle Aged
NAFLD
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - physiopathology
Polymorphism, Single Nucleotide
Postmenopause - genetics
Risk Factors
Type 2 diabetes
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Summary:Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD. We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Glomerular filtration rate (eGFRCKD-EPI) was estimated using the CKD-Epidemiology Collaboration (CKD-EPI) equation, whilst albuminuria was measured with an immunonephelometric assay on morning spot urine samples. NAFLD was detected either by fatty liver index (FLI ≥ 60, n = 101) or by ultrasonography (n = 77). Genotyping was performed by TaqMan-Based RT-PCR system. Eight patients had G/G, 41 G/C and 52 C/C PNPLA3 rs738409 genotypes, and 21 (20.8%) patients had CKD (eGFRCKD-EPI 
ISSN:1262-3636
1878-1780
DOI:10.1016/j.diabet.2019.01.011