Aptamer-functionalized liposomes for targeted cancer therapy

Accumulation of chemotherapeutic agents in the tumor tissue while reducing adverse effects and drug resistance are among the major goals in cancer therapy. Among nanocarriers, liposomes have been found to be more effective in the passive targeting of cancer cells. A promising recent development in t...

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Bibliographic Details
Published in:Cancer letters 2019-04, Vol.448, p.144-154
Main Authors: Moosavian, Seyedeh Alia, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Aptamer
Aptamers
Aptamers, Nucleotide
Cancer
Cancer therapies
Cell Line, Tumor
Chemotherapy
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug dosages
Drug resistance
Humans
Immunoglobulins
Ligands
Liposome
Liposomes
Manufacturing
Medical research
Molecular Targeted Therapy - methods
Nanoparticles
Studies
Targeted cancer therapy
Therapeutic applications
Tumor cells
Tumors
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Summary:Accumulation of chemotherapeutic agents in the tumor tissue while reducing adverse effects and drug resistance are among the major goals in cancer therapy. Among nanocarriers, liposomes have been found to be more effective in the passive targeting of cancer cells. A promising recent development in targeted drug delivery is the use of aptamer-functionalized liposomes for cancer therapy. Aptamer-targeted liposomes have enhanced uptake in tumor cells as shown in vitro and in vivo. Here, we discuss the aptamer-functionalized liposome platforms and review functionalization approaches as well as the factors affecting antitumor efficiency of aptamer-targeted liposomal systems. Finally, we provide a comprehensive overview of aptamer-targeted liposomes based on the molecular targets on the surface of cancer cells. •Targeted drug delivery to tumor cells is a major goal in cancer chemotherapy.•Aptamer-functionalized liposomes have emerged as efficient delivery system for chemotherapeutics.•Aptamer-targeted liposomes have enhanced uptake in tumor cells as shown in vitro and in vivo.•We review the experimental findings and design details of aptamer-targeted liposomes.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2019.01.045