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Porous Graphene Oxide Enhanced Aptamer Specific Circulating-Tumor-Cell Sensing Interface on Light Addressable Potentiometric Sensor: Clinical Application and Simulation

The circulating-tumor-cell (CTC) specific aptamer is believed to be a power recognition factor to realize clinical CTC assay. However, the limited sensing range is still one of the challenges in its real application. The porous-graphene-oxide (PGO) enhanced aptamer specific CTC sensing interface is...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2019-03, Vol.11 (9), p.8704-8709
Main Authors: Li, Fang, Hu, Shihui, Zhang, Rong, Gu, Yajun, Li, Yueguo, Jia, Yunfang
Format: Article
Language:English
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Summary:The circulating-tumor-cell (CTC) specific aptamer is believed to be a power recognition factor to realize clinical CTC assay. However, the limited sensing range is still one of the challenges in its real application. The porous-graphene-oxide (PGO) enhanced aptamer specific CTC sensing interface is studied on the platform of light-addressable-potentiometric-sensor (LAPS) to provide a clinical available method for CTC detection. The underlying mechanism of this sensing interface on LAPS is modeled and simulated. It is confirmed to be a promising candidate for CTC assay by the linear responding for 5–5000 spiked cells, as well as the satisfactory sensitivity for clinical samples.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.8b21101