Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease

Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients wi...

Full description

Saved in:
Bibliographic Details
Published in:Clinica chimica acta 2019-05, Vol.492, p.78-83
Main Authors: Jovanovic, Ljiljana, Subota, Vesna, Stavric, Milena, Subotic, Bojana, Dzudovic, Boris, Novicic, Natasa, Matijasevic, Jovan, Miric, Milica, Salinger, Sonja, Markovic-Nikolic, Natasa, Nikolic, Maja, Miloradovic, Vladimir, Kos, Ljiljana, Kovacevic-Preradovic, Tamara, Marinkovic, Jelena, Kocev, Nikola, Obradovic, Slobodan
Format: Article
Language:English
Subjects:
Biomarkers
Brain natriuretic peptide
Mortality
Pulmonary embolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24 h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882–1.000, p = .001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745–0.902, p 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2019.02.008