Correlation between galectin-3 level in bronchoalveolar lavage fluid and cellular immunity in children with refractory Mycoplasma pneumoniae pneumonia

To study the correlation of galectin-3 level in bronchoalveolar lavage fluid (BALF) with Mycoplasma pneumoniae (MP) load and cellular immunity of neutrophils and macrophages in the airway in children with refractory MP pneumonia (RMPP). A total of 64 children with RMPP who were hospitalized from Jan...

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Bibliographic Details
Published in:Zhongguo dang dai er ke za zhi 2019-02, Vol.21 (2), p.150-154
Main Authors: Zhao, Qian-Ye, Shi, Su-Jie, Sun, Da-Quan, Zhang, Shan-Shan, Zhou, Xu-Hua
Format: Article
Language:Chinese
Subjects:
Bronchoalveolar Lavage Fluid
Child
Galectin 3
Humans
Immunity, Cellular
Mycoplasma pneumoniae
Pneumonia, Mycoplasma
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Summary:To study the correlation of galectin-3 level in bronchoalveolar lavage fluid (BALF) with Mycoplasma pneumoniae (MP) load and cellular immunity of neutrophils and macrophages in the airway in children with refractory MP pneumonia (RMPP). A total of 64 children with RMPP who were hospitalized from January 2013 to January 2017 were enrolled. In addition to the conservative medical treatment, all the 64 children with RMPP were given bronchoalveolar lavage in the acute stage (5-7 days after admission) and 48 out of the 64 children were given bronchoalveolar lavage in the recovery stage (10-14 days after admission). Four milliliters of BALF of the affected lung lobe or segment were collected. ELISA was used to measure the level of galectin-3 in BALF supernatant. RT-PCR was used to measure MP load. Hematoxylin and eosin staining was used to measure the percentage of neutrophils and macrophages. Six children with bronchial foreign bodies were enrolled as the control group. The RMPP group had a significantly higher le
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2019.02.008