Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Earlyand Late-Onset Preeclampsia

We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoc...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-02, Vol.166 (4), p.507-511
Main Authors: Nizyaeva, N. V., Kulikova, G. V., Nagovitsyna, M. N., Shchegolev, A. I.
Format: Article
Language:English
Subjects:
Adult
Age
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chorionic Villi - metabolism
Endothelium
Endothelium, Vascular - metabolism
Female
Gestation
Humans
In Vitro Techniques
Internal Medicine
Intracellular Signaling Peptides and Proteins - metabolism
Laboratory Medicine
Monoclonal antibodies
Paraffin
Pathology
Placenta
Placenta - metabolism
Pre-eclampsia
Pre-Eclampsia - metabolism
Preeclampsia
Pregnancy
Premature birth
Prenatal development
TLR4 protein
Toll-Like Receptor 4 - metabolism
Toll-like receptors
Trophoblasts - metabolism
Young Adult
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Summary:We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04383-6