NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and the Risk of Stroke

Background and Purpose- NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a risk factor for atrial fibrillation and a marker of cardiac function used in the detection of heart failure. Given the link between cardiac dysfunction and stroke, NT-proBNP is a candidate marker of stroke risk. Our a...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2019-03, Vol.50 (3), p.610-617
Main Authors: Di Castelnuovo, Augusto, Veronesi, Giovanni, Costanzo, Simona, Zeller, Tanja, Schnabel, Renate B, de Curtis, Amalia, Salomaa, Veikko, Borchini, Rossana, Ferrario, Marco, Giampaoli, Simona, Kee, Frank, Söderberg, Stefan, Niiranen, Teemu, Kuulasmaa, Kari, de Gaetano, Giovanni, Donati, Maria Benedetta, Blankenberg, Stefan, Iacoviello, Licia
Format: Article
Language:English
Subjects:
Adult
Atrial Fibrillation - complications
Atrial Fibrillation - epidemiology
Biomarkers
Brain Ischemia - blood
Brain Ischemia - epidemiology
Cohort Studies
Europe - epidemiology
Female
Humans
Intracranial Hemorrhages - blood
Intracranial Hemorrhages - epidemiology
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Predictive Value of Tests
Risk Factors
Sex Factors
Stroke - blood
Stroke - epidemiology
Treatment Outcome
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Purpose- NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a risk factor for atrial fibrillation and a marker of cardiac function used in the detection of heart failure. Given the link between cardiac dysfunction and stroke, NT-proBNP is a candidate marker of stroke risk. Our aim was to evaluate the association of NT-proBNP with stroke and to determine the predictive value beyond a panel of established risk factors. Methods- Based on the Biomarkers for Cardiovascular Risk Assessment in Europe-Consortium, we analyzed data of 58 173 participants (50% men; mean age 52 y) free of stroke from 6 community-based cohorts. NT-proBNP measurements were performed in the central Biomarkers for Cardiovascular Risk Assessment in Europe laboratory. The outcomes considered were total stroke and subtypes of stroke (ischemic/hemorrhagic). Results- During a median follow-up time of 7.9 years, we observed 1550 stroke events (1176 ischemic). Increasing quarters of the NT-proBNP distribution were associated with increasing risk of stroke ( P for trend 82.2 pg/mL) had 2-fold (95% CI, 75%-151%) greater risk of stroke than individuals in the lowest quarter (NT-proBNP
ISSN:1524-4628
DOI:10.1161/STROKEAHA.118.023218