The Growth Rate, Immune Status, Duodenal Development, and Cecal Microbial Diversity of 24-Day-Old Offspring of SD Rats Received Bacillus subtilis-Cu or CuSO4 During Pregnancy and Lactation Periods

A total of 108 pregnant and lactation SD rats were divided into six groups, daily and orally dosed with Bacillus subtilis -copper (CuBs) and CuSO 4 (CuS) both at three doses equivalent to 1.5 mg (Cu deficiency), 3 mg, and 6 mg Cu per kg diet, and the effects of the Cu source and dosage on the growth...

Full description

Saved in:
Bibliographic Details
Published in:Biological trace element research 2019-10, Vol.191 (2), p.435-442
Main Authors: Liu, Guodong, Wang, Baowei, Huang, Yanping, Li, Kailing, Ge, Wenhua, Zhang, Mingai, Yue, Bin, Kong, Min
Format: Article
Language:English
Subjects:
Bacillus subtilis
Biochemistry
Biomedical and Life Sciences
Biotechnology
Body weight
Body weight gain
Breastfeeding & lactation
Cecum
Copper
Copper sulfate
Copper sulfides
Dosage
Duodenum
Growth rate
Immune status
Immunoglobulin M
Intestine
Lactation
Life Sciences
Lysozyme
Microorganisms
Nutrition
Offspring
Oncology
Permeability
Pregnancy
Rodents
Serum
Survival
Weight gain
Weight gain measurement
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A total of 108 pregnant and lactation SD rats were divided into six groups, daily and orally dosed with Bacillus subtilis -copper (CuBs) and CuSO 4 (CuS) both at three doses equivalent to 1.5 mg (Cu deficiency), 3 mg, and 6 mg Cu per kg diet, and the effects of the Cu source and dosage on the growth rate, immune status, duodenal development, and cecal microbial diversity were examined on 24-day-old offspring rats. The six offspring rats from each group were randomly selected for measuring the body weight gain and taking blood samples, and three rats were sacrificed for taking duodenum and cecum content samples. We found CuBs increased the body weight gain, development of duodenal villi, and survival rate of the offspring; increased the IgM content and lysozyme activity in serum; reduced the intestinal permeability; and increased the abundances of Lachnospiraceae , Ruminococcaceae , and Intestinibacter in the cecal content, when compared with CuS. We also found that Cu deficiency showed detrimental effects on the body weight gain and length, the survival rate of the offspring, and the immune indices in serum, as well as the increased intestinal permeability. We concluded that CuBs is better Cu source than CuSO 4 for reproductive rats.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-019-1638-5