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Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon
Purpose of Review Studies in humans and animal models show that most recovery from impairment occurs in the first 1–3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to...
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Published in: | Current neurology and neuroscience reports 2019-03, Vol.19 (3), p.13-9, Article 13 |
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Main Author: | |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Purpose of Review
Studies in humans and animal models show that most recovery from impairment occurs in the first 1–3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived “sensitive period” of post-stroke plasticity defined by unique genetic, physiological, and structural events. Unfortunately, rehabilitative interventions in humans have not been able to exploit this sensitive period similar to that seen in animal models. Here, we review these data and suggest a path forward.
Recent Findings
Pre-clinical data reveal underlying mechanisms that define the post-stroke sensitive period. These data are then discussed in the context of the spontaneous post-stroke recovery described in humans.
Summary
Future work will need to capitalize on unique interactions between the sensitive period, spontaneous recovery, and novel types of rehabilitative interventions. |
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ISSN: | 1528-4042 1534-6293 |
DOI: | 10.1007/s11910-019-0927-x |