Loading…

Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon

Purpose of Review Studies in humans and animal models show that most recovery from impairment occurs in the first 1–3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to...

Full description

Saved in:
Bibliographic Details
Published in:Current neurology and neuroscience reports 2019-03, Vol.19 (3), p.13-9, Article 13
Main Author: Zeiler, Steven R.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review Studies in humans and animal models show that most recovery from impairment occurs in the first 1–3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived “sensitive period” of post-stroke plasticity defined by unique genetic, physiological, and structural events. Unfortunately, rehabilitative interventions in humans have not been able to exploit this sensitive period similar to that seen in animal models. Here, we review these data and suggest a path forward. Recent Findings Pre-clinical data reveal underlying mechanisms that define the post-stroke sensitive period. These data are then discussed in the context of the spontaneous post-stroke recovery described in humans. Summary Future work will need to capitalize on unique interactions between the sensitive period, spontaneous recovery, and novel types of rehabilitative interventions.
ISSN:1528-4042
1534-6293
DOI:10.1007/s11910-019-0927-x