3D Scaffolds to Study Basic Cell Biology

Mimicking the properties of the extracellular matrix is crucial for developing in vitro models of the physiological microenvironment of living cells. Among other techniques, 3D direct laser writing (DLW) has emerged as a promising technology for realizing tailored 3D scaffolds for cell biology studi...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2019-06, Vol.31 (26), p.e1808110-n/a
Main Authors: Hippler, Marc, Lemma, Enrico Domenico, Bertels, Sarah, Blasco, Eva, Barner‐Kowollik, Christopher, Wegener, Martin, Bastmeyer, Martin
Format: Article
Language:English
Subjects:
3D scaffolds
Biological effects
Biology
Biomedical engineering
Biomedical materials
cell adhesion
cell mechanics
Direct laser writing
Force measurement
Materials engineering
Scaffolds
Tissue engineering
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Summary:Mimicking the properties of the extracellular matrix is crucial for developing in vitro models of the physiological microenvironment of living cells. Among other techniques, 3D direct laser writing (DLW) has emerged as a promising technology for realizing tailored 3D scaffolds for cell biology studies. Here, results based on DLW addressing basic biological issues, e.g., cell‐force measurements and selective 3D cell spreading on functionalized structures are reviewed. Continuous future progress in DLW materials engineering and innovative approaches for scaffold fabrication will enable further applications of DLW in applied biomedical research and tissue engineering. Among other techniques, direct laser writing (DLW) has emerged as a promising technology for realizing biofunctionalized 3D scaffolds mimicking the properties of the extracellular matrix. Results are reviewed based on DLW addressing basic biological questions, such as selective cell spreading or cell mechanics in a tailored 3D environment.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201808110