Pd/Cu Cocatalyzed Oxidative Tandem C–H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones

The Pd/Cu cocatalyzed oxidative tandem C–H aminocarbonylation and dehydrogenation was developed, affording carbolinones with molecular oxygen as the terminal oxidant. Natural product strychnocarpine and its derivatives were prepared conveniently using this strategy.

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2019-03, Vol.84 (6), p.3357-3369
Main Authors: Han, Hui, Yang, Shang-Dong, Xia, Ji-Bao
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Pd/Cu cocatalyzed oxidative tandem C–H aminocarbonylation and dehydrogenation was developed, affording carbolinones with molecular oxygen as the terminal oxidant. Natural product strychnocarpine and its derivatives were prepared conveniently using this strategy.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b03266