1-Amino-2′-fucosyllactose inhibits biofilm formation by Streptococcus agalactiae

2′-Fucosyllactose (2′-FL) is a ubiquitous oligosaccharide in human milk. Importantly, this carbohydrate promotes the growth of several strains of Bifidobacteria , a class of beneficial gut commensal, and inhibits epithelial binding of pathogens. In light of these protective effects, we elected to ev...

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Bibliographic Details
Published in:Journal of antibiotics 2019-06, Vol.72 (6), p.507-512
Main Authors: Craft, Kelly M., Townsend, Steven D.
Format: Article
Language:English
Subjects:
13
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Bacteriology
Biofilms
Biomedical and Life Sciences
Bioorganic Chemistry
Cell division
Drug resistance
Gene expression
Infections
Life Sciences
Medicinal Chemistry
Metabolism
Microbiology
Milk
Organic Chemistry
Pathogens
Permeability
Special Feature: Brief Communication
Streptococcus infections
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Summary:2′-Fucosyllactose (2′-FL) is a ubiquitous oligosaccharide in human milk. Importantly, this carbohydrate promotes the growth of several strains of Bifidobacteria , a class of beneficial gut commensal, and inhibits epithelial binding of pathogens. In light of these protective effects, we elected to evaluate the potential of 2′-FL to serve as an antibacterial agent against Group B Streptococcus (GBS). While 2′-FL was devoid of any substantial antimicrobial or antibiofilm activity, conversion of 2′-FL to its reducing end β-amine provided a novel antibiofilm compound.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-019-0151-6