Online Sol-gel Capillary Microextraction-Mass Spectrometry (CME-MS) Analysis of Illicit Drugs

Providing rapid and sensitive sample cleanup, sol-gel capillary microextraction (CME) is a form of solid phase microextraction (SPME). The capillary format of CME couples easily with mass spectrometry (MS) by employing sol-gel sorbent coatings in inexpensive fused silica capillaries. By leveraging t...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2019-04, Vol.30 (4), p.595-604
Main Authors: Seyyal, Emre, Evans-Nguyen, Theresa
Format: Article
Language:English
Subjects:
Adsorption
Amphetamines
Analytical Chemistry
Bioinformatics
Biotechnology
Capillaries
Chemistry
Chemistry and Materials Science
Drug abuse
Drugs
Equipment Design
Flow velocity
Fused silica
Humans
Illicit Drugs - isolation & purification
Illicit Drugs - urine
Ligands
Limit of Detection
Mass spectrometry
Mass Spectrometry - methods
Methamphetamine
Narcotics
Organic Chemistry
Phase Transition
Proteomics
Reproducibility
Reproducibility of Results
Research Article
Scientific imaging
Silicon dioxide
Silicon Dioxide - chemistry
Sol-gel processes
Solid Phase Microextraction - instrumentation
Solid Phase Microextraction - methods
Solid phases
Sorbents
Spectroscopy
Substance Abuse Detection - methods
Urine
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Summary:Providing rapid and sensitive sample cleanup, sol-gel capillary microextraction (CME) is a form of solid phase microextraction (SPME). The capillary format of CME couples easily with mass spectrometry (MS) by employing sol-gel sorbent coatings in inexpensive fused silica capillaries. By leveraging the syringe pump and six-port valve readily available on the commercial MS, we can obviate the need for chromatography for samples as complex as urine in quantitative assays. Two different sol-gel materials were studied as microextraction sorbents: one with a single ligand of octadecyl (C 18 ) and the other with a dual-ligand combination of C 18 and phenyl (Phe) groups. The CME-MS method was optimized for flow rate and solvent desorption and studied for overall microextraction performance between the two sorbents studied. We extract illicit drugs including cocaine, heroin, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, and oxycodone, proving good run-to-run reproducibility (RSD%
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-018-02127-w