In vitro effect of curcumin on Schistosoma species viability, tegument ultrastructure and egg hatchability

Schistosomiasis remains a severe problem of public health in developing countries. The development of resistance to praziquantel (PZQ) has justified the search for new alternative chemotherapies with new formulations, more effective, and without adverse effects. Curcumin (CUR), the major phenolic co...

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Bibliographic Details
Published in:Experimental parasitology 2019-04, Vol.199, p.1-8
Main Authors: Abou El Dahab, Marwa M., Shahat, Sondos M., Mahmoud, Soheir S.M., Mahana, Noha A.
Format: Article
Language:English
Subjects:
Curcumin
Egg hatchability
Electron microscopy
ELISA
Schistosoma species
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Summary:Schistosomiasis remains a severe problem of public health in developing countries. The development of resistance to praziquantel (PZQ) has justified the search for new alternative chemotherapies with new formulations, more effective, and without adverse effects. Curcumin (CUR), the major phenolic compound present in rhizome of turmeric (Curcuma longa L.), has been traditionally used against various diseases including parasitic infections. Here, the antischistosomal activity of CUR (50–500 μM), evaluated in parallel against S. mansoni and S. haematobium adult worms, appeared significant (P 
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2019.02.010