RISUG® based improved intrauterine contraceptive device (IIUCD) could impart protective effects against development of endometrial cancer

Intrauterine Contraceptive Devices with multifaceted application potential is a need of an hour. Although, copper-based IUDs exert an effective contraceptive as well as anticancer effects in a long-term basis, but also results in multiple complications. In this regard, RISUG® a polymer based contrac...

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Bibliographic Details
Published in:Medical hypotheses 2019-03, Vol.124, p.67-71
Main Authors: Subramanian, Bhuvaneshwaran, Agarwal, Tarun, Basak, Piyali, Maiti, Tapas Kumar, Guha, Sujoy K.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Endometrial Neoplasms - prevention & control
Female
Humans
Hydrogels
Intrauterine contraceptive device
Intrauterine Devices
Lipid Bilayers
Lipid membrane
Lipids - chemistry
Maleates - chemistry
Phospholipids - chemistry
Polyesters - therapeutic use
Polystyrenes - therapeutic use
RISUG
Uterine carcinoma
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Summary:Intrauterine Contraceptive Devices with multifaceted application potential is a need of an hour. Although, copper-based IUDs exert an effective contraceptive as well as anticancer effects in a long-term basis, but also results in multiple complications. In this regard, RISUG® a polymer based contraceptive device has been introduced as a suitable alternative. However, its potential to impart protective effects against development of endometrial cancer still remains unexplored. This article presents the hypothesis on this unexplored domain and provides scientific facts to support the hypothesis. The mechanism of anticancerous activity is hypothesized that RISUG® involves its lipid membrane destabilizing activity. This activity is modulated by both, the cellular microenvironment and lipid bilayer composition. Acidic environment along with the significantly higher fluidic nature of lipid bilayer of the cancerous cells make them more prone to lipid solubilisation effect of RISUG®. We here present an in-depth insight into the factors that would favour faster solubilisation of cancer cell membrane, thereby exerting an anticancer effect.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2019.02.026