Astrocytic pyruvate carboxylation: Status after 35 years

The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anni...

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Bibliographic Details
Published in:Journal of neuroscience research 2019-08, Vol.97 (8), p.890-896
Main Authors: Schousboe, Arne, Waagepetersen, Helle S., Sonnewald, Ursula
Format: Article
Language:English
Subjects:
anaplerosis
astrocytes
Brain
Carboxylation
cataplerosis
Documents
glutamate
glutamine
Localization
Metabolic pathways
Metabolism
neurons
Pyruvate carboxylase
Pyruvic acid
Tricarboxylic acid cycle
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Summary:The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC‐catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.24402