Gold-catalyzed formation of aryl-fused pyrazolooxazepines via intramolecular regioselective 7-exo-dig cyclization

An efficient method was developed for the synthesis of substituted aryl-fused pyrazolooxazepines from ortho-O-propargyl aryl pyrazoles by gold catalysis. In this organic transformation a new C-N bond was formed regioselectively via 7-exo-dig cyclization. Moderate to good yields of aryl-fused pyrazol...

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Published in:Organic & biomolecular chemistry 2019-03, Vol.17 (10), p.2809-2817
Main Authors: Guduru, Ravinder, Mangina, N S V M Rao, Sridhar, Balasubramanian, Karunakar, Galla V
Format: Article
Language:English
Subjects:
Aromatic compounds
Catalysis
Chemical synthesis
Crystallography
Gold
NMR
Nuclear magnetic resonance
Pyrazoles
Regioselectivity
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creator Guduru, Ravinder
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description An efficient method was developed for the synthesis of substituted aryl-fused pyrazolooxazepines from ortho-O-propargyl aryl pyrazoles by gold catalysis. In this organic transformation a new C-N bond was formed regioselectively via 7-exo-dig cyclization. Moderate to good yields of aryl-fused pyrazolooxazepine derivatives were obtained with significant molecular complexity in one-pot.
doi_str_mv 10.1039/C8OB03157F
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source Royal Society of Chemistry
subjects Aromatic compounds
Catalysis
Chemical synthesis
Crystallography
Gold
NMR
Nuclear magnetic resonance
Pyrazoles
Regioselectivity
title Gold-catalyzed formation of aryl-fused pyrazolooxazepines via intramolecular regioselective 7-exo-dig cyclization
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