Magnetic digital microfluidics on a bioinspired surface for point‐of‐care diagnostics of infectious disease

Magnetic digital microfluidics uses magnetic force to manipulate droplets on a Teflon‐coated substrate through the added magnetic particles. To achieve a wide range of droplet manipulation, hydrophilic patterns, known as surface energy traps, are introduced onto the Teflon‐coated hydrophobic substra...

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Bibliographic Details
Published in:Electrophoresis 2019-04, Vol.40 (8), p.1178-1185
Main Authors: Kanitthamniyom, Pojchanun, Zhang, Yi
Format: Article
Language:English
Subjects:
Antigens
Biomimetics
Coating
Diagnostics
Droplet
Droplets
Hepatitis B
Infectious diseases
Magnetic digital microfluidics
Magnetic fields
Magnetic particles
Microfluidics
Patterning
Polydopamine
Polytetrafluoroethylene
Substrates
Surface energy
Surface properties
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Summary:Magnetic digital microfluidics uses magnetic force to manipulate droplets on a Teflon‐coated substrate through the added magnetic particles. To achieve a wide range of droplet manipulation, hydrophilic patterns, known as surface energy traps, are introduced onto the Teflon‐coated hydrophobic substrate. However, the Teflon‐coated substrate is difficult to modify because it is nonwettable, and existing techniques for patterning surface energy traps have many limitations. Inspired by the mussel adhesion mechanism, we use polydopamine, a bioinspired substance that adheres strongly to almost any materials, to pattern surface energy traps on the Teflon‐coated substrate with a great ease. We have optimized the polydopamine coating protocol and characterized the surface properties of the polydopamine surface energy traps. Droplet operations including particle extraction, liquid dispensing, liquid shaping, and cross‐platform transfer have been demonstrated on the polydopamine surface energy trap‐enabled magnetic digital microfluidic platform in both single‐plate and two‐plate configurations. Furthermore, the detection of hepatitis B surface antigen using ELISA has been demonstrated on the new magnetic dgitial microfluidic platform. This new bioinspired magnetic digital microfluidic platform is easy to fabricate and operate, showing a great potential for point‐of‐care applications.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.201900074