Cytotoxic and Antitumor Activity of some Coumarin Derivatives

Several natural and synthetic coumarins were assayed against different cancer cell lines. Four of them have shown cytotoxicity against a panel of three human solid tumor cell lines (HeLa, T-47D, and WiDr) and a clearly activity/hydrophobicity relationship. Compound 13 proved to be the most active pr...

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Bibliographic Details
Published in:Natural product communications 2016-09, Vol.11 (9), p.1289-1292
Main Authors: Garro, Hugo A., Reta, Guillermo F., Donadel, Osvaldo J., Pungitore, Carlos R.
Format: Article
Language:English
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Summary:Several natural and synthetic coumarins were assayed against different cancer cell lines. Four of them have shown cytotoxicity against a panel of three human solid tumor cell lines (HeLa, T-47D, and WiDr) and a clearly activity/hydrophobicity relationship. Compound 13 proved to be the most active product in all cell lines tested, with values of 8.0 (±0.38) μM against HeLa cells and also able to inhibit Taq DNA polymerase. This dual activity of 13 makes it a candidate to be considered as a “lead” compound in the search for novel antitumor drugs.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1601100926