Irisin and BDNF serum levels and behavioral disturbances in Alzheimer’s disease

Behavioral dysfunctions (BPSD) represent the most important problem in Alzheimer’s dementia (AD) management. We assessed the serum levels of two myokines in AD patients, preliminary investigating, as secondary aim, their role as potential biomarkers for agitation/aggression (AA) and aberrant motor b...

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Published in:Neurological sciences 2019-06, Vol.40 (6), p.1145-1150
Main Authors: Conti, Elisa, Grana, Denise, Stefanoni, Giovanni, Corsini, Alberto, Botta, Margherita, Magni, Paolo, Aliprandi, Angelo, Lunetta, Christian, Appollonio, Ildebrando, Ferrarese, Carlo, Tremolizzo, Lucio
Format: Article
Language:English
Subjects:
Agitation
Alzheimer's disease
Behavior
Biomarkers
Brain-derived neurotrophic factor
Caregivers
Cognitive ability
Dementia
Dementia disorders
Enzyme-linked immunosorbent assay
Exercise
Hallucinations
Hospitals
Medicine
Medicine & Public Health
Motor activity
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Patients
Physical fitness
Psychiatry
Psychosis
Serum levels
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Summary:Behavioral dysfunctions (BPSD) represent the most important problem in Alzheimer’s dementia (AD) management. We assessed the serum levels of two myokines in AD patients, preliminary investigating, as secondary aim, their role as potential biomarkers for agitation/aggression (AA) and aberrant motor behavior (AMB): irisin, since it is able to modify the motor pattern, and BDNF, since it was transcribed following irisin stimulation. Forty AD patients were recruited and characterized according to the expressed neuropsychiatric syndrome. Myokines were measured by ELISA. Irisin serum levels were slightly elevated in AA+ patients (+ 10.0%; p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-019-03781-y