Recent developments in bioreactor scale production of bacterial polyhydroxyalkanoates

Polyhydroxyalkanoates (PHAs) are biological plastics that are sustainable alternative to synthetic ones. Numerous microorganisms have been identified as PHAs producers. They store PHAs as cellular inclusions to use as an energy source backup. They can be produced in shake flasks and in bioreactors u...

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Bibliographic Details
Published in:Bioprocess and biosystems engineering 2019-06, Vol.42 (6), p.901-919
Main Authors: Raza, Zulfiqar Ali, Tariq, Muhammad Rizwan, Majeed, Muhammad Irfan, Banat, Ibrahim M.
Format: Article
Language:English
Subjects:
Bioreactors
Biotechnology
Carbon
Carbon sources
Cell culture
Chemistry
Chemistry and Materials Science
Commercialization
Critical Review
Dissolved oxygen
Drug delivery systems
Environmental Engineering/Biotechnology
Fermentation
Flasks
Food Science
Inclusions
Industrial and Production Engineering
Industrial Chemistry/Chemical Engineering
Laboratories
Microorganisms
Nutrients
Plastics
Polyhydroxyalkanoates
Polymers
Vegetable oils
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Summary:Polyhydroxyalkanoates (PHAs) are biological plastics that are sustainable alternative to synthetic ones. Numerous microorganisms have been identified as PHAs producers. They store PHAs as cellular inclusions to use as an energy source backup. They can be produced in shake flasks and in bioreactors under defined fermentation and physiological culture conditions using suitable nutrients. Their production at bioreactor scale depends on various factors such as carbon source, nutrients supply, temperature, dissolved oxygen level, pH, and production modes. Once produced, PHAs find diverse applications in multiple fields of science and technology particularly in the medical sector. The present review covers some recent developments in sustainable bioreactor scale production of PHAs and identifies some areas in which future research in this field might be focused.
ISSN:1615-7591
1615-7605
DOI:10.1007/s00449-019-02093-x