Tumour necrosis factor superfamily members in ischaemic vascular diseases

Abstract Current treatment of ischaemic vascular diseases such as coronary and peripheral artery disease includes angioplasty and bypass grafting, as well as lipid lowering therapies and control of other cardiovascular risk factors. Numerous members of the tumour necrosis factor superfamily (TNFSF)...

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Bibliographic Details
Published in:Cardiovascular research 2019-03, Vol.115 (4), p.713-720
Main Authors: Nash, Megan, McGrath, Jordan P, Cartland, Siân P, Patel, Sanjay, Kavurma, Mary M
Format: Article
Language:English
Subjects:
Animals
Arteries - drug effects
Arteries - metabolism
Arteries - pathology
Arteries - physiopathology
CD40 Ligand - metabolism
Cytokine TWEAK - metabolism
Humans
Ischemia - drug therapy
Ischemia - metabolism
Ischemia - pathology
Ischemia - physiopathology
Receptors, Tumor Necrosis Factor - metabolism
Signal Transduction
TNF-Related Apoptosis-Inducing Ligand - metabolism
Tumor Necrosis Factor Inhibitors - therapeutic use
Tumor Necrosis Factor-alpha - metabolism
Tumor Necrosis Factors - metabolism
Tumor Necrosis Factors - therapeutic use
Vascular Diseases - drug therapy
Vascular Diseases - metabolism
Vascular Diseases - pathology
Vascular Diseases - physiopathology
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Summary:Abstract Current treatment of ischaemic vascular diseases such as coronary and peripheral artery disease includes angioplasty and bypass grafting, as well as lipid lowering therapies and control of other cardiovascular risk factors. Numerous members of the tumour necrosis factor superfamily (TNFSF) have recently shown emerging roles in both the protection and progression of such diseases. Understanding the role TNFSF members play in ischaemic vascular disease may provide insight into the development of novel therapeutics to prevent or treat diseases relating to atherosclerosis and ischaemia. This review summarizes the most recent findings relating to TNFSF members and the mechanisms that precede ischaemic vascular disease progression, particularly endothelial dysfunction, chronic inflammation, and atherosclerotic plaque development. This review also explores recent translational research on the role of TNFSF therapies in cardiovascular disease.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvz042