Utility of osteopontin in cerebrospinal fluid as a diagnostic marker for neuropsychiatric systemic lupus erythematosus

The whole protein of osteopontin (OPN full) and its cleaved form (OPN N-half) are involved in the immune response and the migration of immune cells to an inflammatory lesion. We have reported that serum OPN full and urine OPN N-half are elevated in lupus nephritis (LN). Neuropsychiatric systemic lup...

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Bibliographic Details
Published in:Lupus 2019-03, Vol.28 (3), p.414-422
Main Authors: Kitagori, K, Yoshifuji, H, Oku, T, Ayaki, T, Kuzuya, A, Nakajima, T, Akizuki, S, Nakashima, R, Murakami, K, Ohmura, K, Hirayama, Y, Takahashi, R, Mimori, T
Format: Article
Language:English
Subjects:
Cell migration
Cerebrospinal fluid
Chemokines
Correlation analysis
Cytokines
Immune response
Inflammation
Interleukin 6
Lupus
Lupus nephritis
Nephritis
Neurological complications
Osteopontin
Systemic lupus erythematosus
Urine
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Summary:The whole protein of osteopontin (OPN full) and its cleaved form (OPN N-half) are involved in the immune response and the migration of immune cells to an inflammatory lesion. We have reported that serum OPN full and urine OPN N-half are elevated in lupus nephritis (LN). Neuropsychiatric systemic lupus erythematosus (NPSLE) is a refractory complication of SLE. To investigate whether OPN full and OPN N-half could serve as diagnostic markers for NPSLE, and to elucidate their role in NPSLE pathogenesis, the concentrations of OPN full and OPN N-half in cerebrospinal fluid (CSF) were measured in NPSLE and non-NPSLE patients. We found that the concentration of OPN full in the CSF was significantly higher in NPSLE than in non-NPSLE, and it decreased after treatment. When the cutoff value of OPN full in CSF was set to 963.4 ng/ml, the sensitivity and specificity for the diagnosis of NPSLE were 70% and 100%, respectively. The correlation analysis of OPN full, OPN N-half and various cytokines/chemokines suggested that the cytokines/chemokines could be divided into two clusters: cluster A, which contains OPN full and cluster B, which contains interleukin-6. OPN full in CSF could be a novel diagnostic marker for NPSLE.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203319828818