MiRNA as biomarker for uveitis - A systematic review of the literature

• Published in: Gene 2019-05, Vol.696, p.162-175
• Main Authors: Pockar, Sasa, Globocnik Petrovic, Mojca, Peterlin, Borut, Vidovic Valentincic, Natasa
• Format: Article
• Language: English
• Subjects: Biomarkers; Intracoular inflammation; miRNA; Uveitis
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2019.02.004

A systematic review of miRNA profiling studies in uveitis. Literature search strategy - Pubmed central central database, using miRNA/microRNA and intraocular inflammation/uveitis as keywords. We found twenty publications regarding the experimental and clinical use of miRNA in uveitis, published between 2011 and 2018. The publications regarding the role of miRNA in uveitis are very scarce, but provide some valuable information about the potential new mechanisms in uveitis. Some of the identified miRNAs in different uveitis entities could serve as a biomarker of intraocular inflammation. Possible candidate miRNAs could be let-7e, miRNA-1, miR-9-3, miR-20a-5p, miR-23a, mir-29a-3p, miR-140-5p, miR-143, miR-146a and miR-146a-5p, miR-155, miR-182 and miR-182-5p, miR-196a2, miR-205, miR-223-3p, miR-301a. MiR-146a, miR-146a-5p, miR-155, miR-182, miR-223-3p, have been found to be possibly associated with uveitis disease in both, human and animal species. •Some miRNAs could be potential new biomarkers in diagnosing intraocular inflammation•The publications regarding the role of miRNA in uveitis are very scarce•Most miRNA found to be differentially expressed in these studies have been shown to have a role in immunity•According to the literature review, miR-155 and miR-146a could be biomarkers in human uveitis•miR-146a, miR-146a-5p, miR-155, miR-182, miR-223-3p, could be associated with uveitis in human and animals