Sex-specific differences in the association of vitamin D with low lean mass and frailty: Results from the Berlin Aging Study II

•Vitamin D insufficiency is not only highly prevalent in community-dwelling older people regardless of sex but also associated with low lean mass and prefrailty/frailty.•This association with low lean mass has striking sex-specific differences: Vitamin D insufficiency is associated with low lean mas...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2019-06, Vol.62, p.1-6
Main Authors: Spira, Dominik, Buchmann, Nikolaus, König, Maximilian, Rosada, Adrian, Steinhagen-Thiessen, Elisabeth, Demuth, Ilja, Norman, Kristina
Format: Article
Language:English
Subjects:
Aging
Biomarkers
Body composition
Body mass index
Body size
Dual energy X-ray absorptiometry
Frailty
Frailty criteria
Gender differences
Life span
Low lean mass
Men
Phenotypes
Risk analysis
Risk factors
Sarcopenia
Sex
Vitamin D
Vitamin D insufficiency
Walking
Women
Womens health
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Summary:•Vitamin D insufficiency is not only highly prevalent in community-dwelling older people regardless of sex but also associated with low lean mass and prefrailty/frailty.•This association with low lean mass has striking sex-specific differences: Vitamin D insufficiency is associated with low lean mass in men only.•Vitamin D status might be a biomarker for early development of frailty in the aging process. Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype. A total of 1102 participants (51% women) from the Berlin Aging Study II were included in this cross-sectional study. Vitamin D insufficiency was defined as a 25(OH)D level
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2018.11.020