Synthesis and Antimicrobial Properties of Novel Phosphonium Salts Bearing 1,4‐Dihydroxyaryl Fragment

A versatile two‐step pathway to the synthesis of triaryl(2,5‐dihydroxy‐6‐methyl‐3‐(propan‐2‐yl)phenyl)‐ and triaryl(1,4‐dihydroxynaphthyl)phosphonium salts from triarylphosphonium trifluoroacetates was developed. The reaction proceeds under mild conditions (20 °C, CH2Cl2) with high yields (88–95 %)....

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2019-05, Vol.16 (5), p.e1900039-n/a
Main Authors: Khasiyatullina, Nadezhda R., Mironov, Vladimir F., Voloshina, Alexandra D., Sapunova, Anastasiya S.
Format: Article
Language:English
Subjects:
1,4-naphthoquinone
antibacterial activity
Antimicrobial agents
Bactericidal activity
Dichloromethane
H-phosphonium salt
Salts
Synthesis
synthesis design
tertiary phosphine
tetraarylphosphonium salt
thymoquinone
Trifluoroacetates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A versatile two‐step pathway to the synthesis of triaryl(2,5‐dihydroxy‐6‐methyl‐3‐(propan‐2‐yl)phenyl)‐ and triaryl(1,4‐dihydroxynaphthyl)phosphonium salts from triarylphosphonium trifluoroacetates was developed. The reaction proceeds under mild conditions (20 °C, CH2Cl2) with high yields (88–95 %). Some representatives of this series possess low hemolytic and high bactericidal activity against Gram‐positive bacteria.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201900039