The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto’s thyroiditis: A pilot study

• Published in: Pharmacological reports 2019-04, Vol.71 (2), p.243-247
• Main Authors: Krysiak, Robert, Szkróbka, Witold, Okopień, Bogusław
• Format: Article
• Language: English
• Subjects: Adult; Autoantibodies - blood; Autoantigens - blood; Autoimmunity - immunology; Dietary Supplements; Drug Safety and Pharmacovigilance; Hashimoto Disease - blood; Hashimoto Disease - immunology; Humans; Hypothalamo-Hypophyseal System - metabolism; Iodide Peroxidase - blood; Iron-Binding Proteins - blood; Male; Original Article; Pharmacotherapy; Pharmacy; Pilot Projects; Pituitary Gland - metabolism; Selenium; Selenomethionine - administration & dosage; Selenomethionine - pharmacology; Thyroid autoimmunity; Thyroid Function Tests; Thyroid Hormones - blood; Thyrotropin - blood; Vitamin D; Vitamin D - administration & dosage; Vitamin D - analogs & derivatives; Vitamin D - blood
• ISSN: 1734-1140; 2299-5684
• DOI: 10.1016/j.pharep.2018.10.012

Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto’s thyroiditis. The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel’s thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study. At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D. Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto’s thyroiditis.