Clinical usefulness of brain-derived neurotrophic factor and visinin-like protein-1 in early diagnostic tests for acute stroke

• Published in: The American journal of emergency medicine 2019-11, Vol.37 (11), p.2051-2054
• Main Authors: Algin, Abdullah, Erdogan, M. Ozgur, Aydin, Irfan, Poyraz, M. Kaan, Sirik, Mehmet
• Format: Article
• Language: English
• Subjects: Acute stroke; Adult; Age; Aged; Aged, 80 and over; BDNF; Biomarkers - blood; Blood; Body mass index; Brain; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Case-Control Studies; Cholesterol; Chronic illnesses; Diagnostic tests; Early Diagnosis; Emergency department; Emergency medical care; Emergency Service, Hospital; Female; Humans; Ischemia; Male; Medical diagnosis; Middle Aged; Mortality; Neurocalcin; Neurocalcin - blood; NMR; Nuclear magnetic resonance; Patients; Prospective Studies; Proteins; ROC Curve; Standard deviation; Stroke; Stroke - blood; Stroke - diagnosis; Stroke - mortality; VILIP-1; Vitamin B
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/j.ajem.2019.02.037

Lack of a rapid biochemical test for acute stroke is a limitation in the diagnosis and management of acute stroke. The aim of this study is to evaluate the efficacy of BDNF and VILIP-1 as diagnostic markers in acute ischemic stroke and as predictors of mortality. The study included 75 patients with acute ischemic stroke older than 18 years. During the same period, 28 normal controls were recruited from the hospital ED. Blood samples were collected from all patients at admission to determine the levels of VILIP-1 and BDNF. The mean VILIP-1 levels in the study and control groups were 0.547 ± 0.081 and 0.515 ± 0.035 ng/mL, respectively, and the difference was not significant (p = 0.071). The mean BDNF levels in the study and control groups were 3.89 ± 2.05 ng/mL and 14.9 ± 4.7 ng/mL, respectively, and the level was significantly (p