Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis

Skin dryness is a characteristic of rheumatoid arthritis (RA) model mice. However, the mechanism underlying the induction of dry skin by RA is unclear. We hypothesized that T helper (Th)2 and Th17 cells mediate this process. A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with T...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2019/03/01, Vol.42(3), pp.468-474
Main Authors: Goto, Kenji, Hiramoto, Keiichi, Ooi, Kazuya
Format: Article
Language:English
Subjects:
Arthritis
Collagen
dendritic cell
dry skin
Helper cells
Hypersensitivity
Interleukin 17
Interleukin 6
Lymphocytes T
Mice
Plasma levels
Rheumatoid arthritis
Skin
T helper 17 cell
T helper 2 cell
Thymic stromal lymphopoietin
Thymus
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Water loss
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Summary:Skin dryness is a characteristic of rheumatoid arthritis (RA) model mice. However, the mechanism underlying the induction of dry skin by RA is unclear. We hypothesized that T helper (Th)2 and Th17 cells mediate this process. A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with Th2 or Th17 cell inhibitor, and transepidermal water loss (TEWL) and the expression of markers associated with allergic reaction and inflammation were evaluated. TEWL and plasma levels of thymic stromal lymphopoietin, interleukin (IL)-6 and -17, and tumor necrosis factor (TNF)-α were increased in the arthritis mouse model compared to that in control mice. Administration of Th2 cell inhibitor abolished the increase in TEWL, IL-6, and TNF-α levels, whereas Th17 cell inhibitor reversed TEWL and decreased IL-17 level. Th2 and Th17 cells contribute to the induction of dry skin, but via distinct mechanisms.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b18-00803