Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

It has been extensively verified that inflammation and oxidative stress play important roles in the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma longa, have three major active ingredients, which include curcumin (curcumin I), demethoxycurcumin, and bisdemethox...

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Bibliographic Details
Published in:Phytotherapy research 2019-05, Vol.33 (5), p.1302-1317
Main Authors: Li, Cheng, Miao, Xiao, Li, Fengsheng, Adhikari, Binay Kumar, Liu, Yucheng, Sun, Jian, Zhang, Rong, Cai, Lu, Liu, Quan, Wang, Yonggang
Format: Article
Language:English
Subjects:
Animal research
Animals
Arteriosclerosis
Atherosclerosis
cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - pathology
Clinical trials
Complications
Curcuma - chemistry
Curcumin
curcuminoids
Diabetes mellitus
Heart diseases
Humans
Hypertension
Hypertrophy
Inflammation
Inflammation - drug therapy
Injury prevention
Ischemia
Medical research
Oxidation
Oxidative Stress
Pathogenesis
Plant Extracts - chemistry
Reperfusion
Therapeutic applications
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Summary:It has been extensively verified that inflammation and oxidative stress play important roles in the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma longa, have three major active ingredients, which include curcumin (curcumin I), demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have been used in traditional medicine for CVDs' management and other comorbidities for centuries. Numerous studies had delineated their anti‐inflammatory, antioxidative, and other medicinally relevant properties. Animal experiments and clinical trials have also demonstrated that turmeric and curcuminoids can effectively reduce atherosclerosis, cardiac hypertrophy, hypertension, ischemia/reperfusion injury, and diabetic cardiovascular complications. In this review, we introduce and summarize curcuminoids' molecular and biological significance, while focusing on their mechanistic anti‐inflammatory/antioxidative involvements in CVDs and preventive effects against CVDs, and, finally, discuss relevant clinical applications.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6324