Extracellular vesicles: Squeezing every drop of regenerative potential of umbilical cord blood

Collection, cryopreservation and transplantation of umbilical cord blood (UCB)-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. Indeed, increasing evidence shows that extracellular vesicles (EV), which in...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2019-06, Vol.95, p.102-104
Main Authors: Roura, Santiago, Vives, Joaquim
Format: Article
Language:English
Subjects:
Animals
Bone formation
Cell Differentiation
Cell-free therapy
Extracellular Vesicles
Fetal Blood
Hematopoietic Stem Cells
Humans
Mesenchymal Stem Cells
Mice
MicroRNAs
Osteogenesis
Regenerative medicine
Umbilical cord blood
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Summary:Collection, cryopreservation and transplantation of umbilical cord blood (UCB)-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. Indeed, increasing evidence shows that extracellular vesicles (EV), which include a heterogeneous pool of membranous structures secreted by the vast majority of cells, can serve as powerful tools for cell-free therapy due to precise multifunctional molecular cargoes. In this issue, Hu et al. [1] described that EV extracted from UCB (UCB-EV) ameliorate bone loss in senile osteoporotic mice and promote in vitro osteoblast differentiation of bone marrow-derived Mesenchymal Stromal Cells through miR-3960-mediated signaling. These results envision the capability of UCB-EV of priming multipotent stem cells toward the osteogenic cell lineage and interfering on bone resorption processes. Although processing and manufacturing of EV-based products have to further develop major issues, we foresee that EV will soon become new therapeutic products supplied by UCB banks for treating human diseases, including bone-related conditions. •UCB is the most popular source of cell-based products for transplantation.•EV are multifunctional cell-derived structures which act in a paracrine manner.•EV have notably attracted the attention of researchers for regenerative treatments.•miR-3960 is abundant in UCB-EV and promote osteogenesis both in vitro and in vivo.•These EV will be useful tools to treat human conditions requiring bone formation.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2019.02.006